The Science

Imperial College Psilocybin Research: What the Studies Have Found

A summary of the most influential research center in modern psychedelic science — the Imperial College London team that produced the first fMRI study of psilocybin and the first head-to-head trial against an SSRI.

James Fadiman: The Father of the Modern Microdosing Protocol

Dr. James Fadiman is the researcher most responsible for the modern microdosing protocol. Here is who he is, what his research has actually documented, and where the protocol came from.

Memory Reconsolidation and Trauma: How Psilocybin May Help

A research-backed look at memory reconsolidation, the neuroscience that explains how trauma memories can be modified, and how psilocybin may enhance this window for healing work.

Microdosing for ADHD: What the Research Shows

A research-backed look at what the science actually shows about microdosing for ADHD — the small but growing evidence base, the proposed mechanisms, and the limits of what we currently know.

Microdosing for Depression and Anxiety: What the Research Shows

A research-backed look at what the published science actually shows about microdosing for depression and anxiety. The major studies, the limits of the data, and what the field still does not know.

Psilocybin and Neuroplasticity: How the Brain Rewires Itself

How psilocybin promotes growth of new neural connections in the brain — what the rodent and human research shows, and the limits of what we currently know.

Psilocybin vs Psilocin: The Active Compound, Explained

Psilocybin and psilocin are two different molecules. One is in the mushroom. The other is what your body actually responds to. Here is how the conversion works and why it matters.

Serotonin Syndrome and Psychedelics: The Real Risks

A clear breakdown of serotonin syndrome — what it is, what causes it, which psychedelic combinations actually carry real risk, and how to recognize the symptoms.

SSRI Emotional Blunting: Why Antidepressants Make You Feel Numb

Emotional blunting is one of the most common and least talked-about side effects of long-term SSRI use. Here is what causes it, how common it is, and what the research says about reversing it.

SSRIs and Psilocybin: Combination Risks and the Tapering Conversation

What the research actually shows about combining SSRIs and psilocybin, why most people on SSRIs feel little from microdoses, and how to think about tapering safely if you want to start a microdosing practice.

The 5-HT2A Serotonin Receptor: How Psilocybin and SSRIs Compete

A clear explanation of the 5-HT2A serotonin receptor — what it does, why it is the molecular target of psilocybin and other classic psychedelics, and how SSRIs interact with the same system.

The Default Mode Network: How Psilocybin Quiets Your Inner Static

A clear, research-backed explanation of the Default Mode Network, what it is, why it matters in depression and anxiety, and how psilocybin temporarily quiets it.

What Is Microdosing? The Honest Primer

What microdosing actually is, how it works, who it's for, what it isn't, and what the research does and doesn't support. The plain-language primer the rest of the internet should have written.